Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity

YS Chen, HM Yu, JJ Shie, TJR Cheng, CY Wu…

Index: Chen, Yuan-Siao; Yu, Hui-Ming; Shie, Jiun-Jie; Cheng, Ting-Jen Rachel; Wu, Chung-Yi; Fang, Jim-Min; Wong, Chi-Huey Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1766 - 1772

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Citation Number: 6

Abstract

Abstract This study demonstrates that compounds 1–4 from an extract of Plectranthus amboinicus inhibit the binding of AP-1 to its consensus DNA sequence. Thymoquinone (5) was further identified as a nonpolar ingredient from the hexane extract of P. amboinicus to suppress the expression of lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-α). We then synthesized 2-alkylidenyl-4-cyclopentene-1, 3-diones as the designed ...