Novel 4-(6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolin-2-yl) methylbenzofuran derivatives as selective α 2C-adrenergic receptor antagonists

…, J Enokizono, S Uchida, H Nonaka, M Kurokawa…

Index: Hagihara, Koji; Kashima, Hajime; Iida, Kyoichiro; Enokizono, Junichi; Uchida, Shin-ichi; Nonaka, Hiromi; Kurokawa, Masako; Shimada, Junichi Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1616 - 1621

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Citation Number: 9

Abstract

The synthesis of a series of 4-(6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolin-2-yl) methyl-2- arylbenzofuran and 4-(6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolin-2-yl) methylbenzofuran-2-carboxamide derivatives as novel α2C-adrenergic receptor antagonists are described. Their affinity at three different human α2-adrenergic receptors is reported, and some of these compounds exhibited high affinity for the α2C-adrenergic receptor with ...