A novel series of N-(hexahydr-1, 4-diazepin-6-yl) and N-(hexahydroazepin-3-yl) benzamides with high affinity for 5-HT 3 and dopamine D 2 receptors

Y Hirokawa, T Morie, H Yamazaki, N Yoshida…

Index: Hirokawa, Yoshimi; Morie, Toshiya; Yamazaki, Hiroshi; Yoshida, Naoyuki; Kato, Shiro Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 6 p. 619 - 624

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Citation Number: 14

Abstract

A novel series of benzamides with a hexahydro-1, 4-diazepine or hexahydroazepine ring in the amine moiety were prepared, and their binding affinities for 5-HT3 and dopamine D2 receptors were evaluated. The R isomer of the 1-ethyl-4-methylhexahydro-1, 4- diazepinylbenzamide (R)-22 had potent affinity for both receptors. The R-enantiomer of the corresponding 1-ethylhexahydroazepinylbenzamide 28 showed potent affinity for ...