Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Laura Broutier, Gianmarco Mastrogiovanni, Monique MA Verstegen, Hayley E Francies, Lena Morrill Gavarró, Charles R Bradshaw, George E Allen, Robert Arnes-Benito, Olga Sidorova, Marcia P Gaspersz, Nikitas Georgakopoulos, Bon-Kyoung Koo, Sabine Dietmann, Susan E Davies, Raaj K Praseedom, Ruby Lieshout, Jan N M IJzermans, Stephen J Wigmore, Kourosh Saeb-Parsy, Mathew J Garnett, Luc JW van der Laan, Meritxell Huch

Index: 10.1038/nm.4438

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Abstract

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening Human primary liver cancer–derived organoid cultures for disease modeling and drug screening, Published online: 13 November 2017; doi:10.1038/nm.4438NatureArticleSnippet(type=short-summary, markup= Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment., isJats=true)