Combination of the Suzuki–Miyaura cross-coupling and nucleophilic aromatic substitution of hydrogen (HSN) reactions as a versatile route to pyrimidines bearing …

…, PA Slepukhin, MI Kodess, MA Ezhikova, MG Pervova…

Index: Verbitskiy, Egor V.; Cheprakova, Ekaterina M.; Slepukhin, Pavel A.; Kodess, Mikhail I.; Ezhikova, Marina A.; Pervova, Marina G.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N. Tetrahedron, 2012 , vol. 68, # 27-28 p. 5445 - 5452

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Citation Number: 27

Abstract

It has been shown that combination of the Suzuki–Miyaura cross-coupling and nucleophilic aromatic substitution of hydrogen is a versatile method for the synthesis of 4-(thiophen-2-yl)-, 5-(thiophen-2-yl)-, and 4, 5-di (thiophen-2-yl) substituted pyrimidines from the commercially available 5-bromopyrimidine. The [Formula: see text](AE)-and [Formula: see text](AO)- reactions of 5-bromopyrimidine with thiophene and 2-bromothiophene have been studied ...