Modified Knoevenagel–Stobbe preparation of substituted pyridines: a new approach to streptonigrinoids

MA Ciufolini, NE Byrne

Index: Ciufolini, Marco A.; Byrne, Norman E. Journal of the Chemical Society, Chemical Communications, 1988 , # 18 p. 1230 - 1231

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Abstract

We describe here a modified Knoevenagel-Stobbel prepara- tion of 2,4-disubstituted pyridines. It was found that 13- dicarbonyl compounds required for that reaction may be obtained, in protected form, by the recently developed ... Table 1. Yields for the reactions in Scheme 1 ... Rl = Phenyl Phenyl (E)-P-Styryl 2-Fury1 Phenyl Phenyl Phenyl ... R2 = Phenyl Phenyl Phenyl Phenyl Cyclo hexyl n - N ony 1 2-Fury1 ... (2) R3 = H Me H H H H H

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