Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV

H O'Dowd, DE Shannon, KR Chandupatla…

Index: Bentley, Arthur; Butters, Michael; Green, Stuart P.; Learmonth, William J.; MacRae, Julie A.; Morland, Matthew C.; O'Connor, Garry; Skuse, Joanne Organic Process Research and Development, 2002 , vol. 6, # 2 p. 109 - 112

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Citation Number: 2

Abstract

Benzimidazole 1 is the lead compound resulting from an antibacterial program targeting dual inhibitors of bacterial DNA gyrase and topoisomerase IV. With the goal of improving key drug-like properties, namely, the solubility and the formulability of 1, an effort to identify