Analogs of Spermine and Spermidine. I. Synthesis of Polymethylenepolyamines by Reduction of Cyanoethylated α, ι-Alkylenediamines1, 2

M Israel, JS Rosenfield, EJ Modest

Index: Israel,M. et al. J. Med. Chem., 1964 , vol. 7, p. 710 - 716

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Citation Number: 90

Abstract

Kovember, 1964 ANALOGS OF SPERMINE AI~ D SPERMIDINE. I 71 1 warming to complete the reaction, was intended to decrease the possibility of dicyanoethylation. How-ever, with the lower niolecular weight diamines, dicyanoethylation could not be avoided entirely, the yield of the dicyanoethylated product decreasing with increasing methylene chain length. The cyanoethylated products were purified, wherever possible, by vacuum distillation of ...