Discovery and development of a commercial synthesis of azafenidin

R Shapiro, R DiCosimo, SM Hennessey…

Index: Organic Process Research and Development, , vol. 5, # 6 p. 593 - 598

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Citation Number: 29

Abstract

... of propargyl alcohol with benzenesulfonyl chloride in aqueous caustic, and the crude organic layer can be ... by alkylating the phenol at the final step rather than earlier in the process. ... C. 2,4-Dichloro-5-acetamidophenol (3) was prepared by a modification of a literature procedure. ...