Convenient Syntheses of Daunomycinone??7??D??Glucuronides and Doxorubicinone??7??D??Glucuronides

YS Rho, SY Kim, WJ Kim, YK Yun, HS Sin…

Index: Rho, Young S.; Kim, Sun Y.; Kim, Wan-Joong; Yeo, Keun Yun; Hong, Sig Sin; Dong, Jin Yoo Synthetic Communications, 2004 , vol. 34, # 19 p. 3497 - 3511

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Citation Number: 5

Abstract

Abstract The first synthesis of new doxorubicin and daunomycin analogs containing glucuronic acid moieties instead of daunosamine are described. The desired products, daunomycinone??7??D??glucuronide (DM7G, 10) and doxorubicinone??7??D??glucuronide (DX7G, 11) were conveniently prepared through the glycosylation at 7??hydroxyl group of daunomycinone (4) or 14??acetoxydoxorubicinone (6) with glucuronic acid derivative 7 by ...

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