Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression

…, KC Marsh, AJ Kempf-Grote, P Kilgannon…

Index: Ito, Yoshikatsu; Kunimoto, Kazuhiko; Miyachi, Shigehiro; Kako, Takeshi Tetrahedron Letters, 1991 , vol. 32, # 32 p. 4007 - 4010

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Citation Number: 48

Abstract

... Volume: Page: ... 2,3-c]pyridines were accomplished as shown in Scheme 2. In a method analogous to that of Ito, 19 deprotonation ... A carboxyl group was then introduced into the 2-position by deprotonation using n-butyllithium in tetrahydrofuran at low temperature ...