Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine

G Zhang, L Zha

Index: Research on Chemical Intermediates, , vol. 39, # 6 p. 2303 - 2309

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Abstract

... Research on Chemical Intermediates. ... All reagents and raw materials were analytical-reagent grade or chemically pure, and were treated conventionally before use. ... 4,5-bis(2-methoxyethoxy)- 2-nitrobenzoate (6) was prepared by direct nitration in previous research, but when ...