Antagonism of 1-(2, 5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2-versus 5-HT1C-selective antagonist

AM Ismaiel, J De Los Angeles, M Teitler…

Index: Ismaiel; De los Angeles; Teitler; Ingher; Glennon Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2519 - 2525

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Citation Number: 55

Abstract

DOM [ie, l-(2, 5-dimethoxy-4-methylphenyl)-2-aminopropanel is a 5-HTlcp serotonin agonist that exerts stimulus control of behavior in animals. In order to determine if the discriminative stimulus effect of DOM is 5-HTlc-or 5-HTz-mediated, it would be informative to conduct tests of stimulus antagonism with a 5-HTlc-or 5-HT2-selective antagonist. To date, no such agents exist. Although the neuroleptic agent spiperone binds at D2 dopamine receptors and B-HT ...