Journal of the American Chemical Society

Some Derivatives of 3-Pyridol with Parasympathomimetic Properties1

HM Wuest, EH Sakal

Index: Wuest; Sakal Journal of the American Chemical Society, 1951 , vol. 73, p. 1210,1214

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Citation Number: 30

Abstract

Stedman's" meta" compound (11) was as unstable as physostigmine (I) in aqueous solution. This led Aeschlimann and Reinert3 to produce a more stable derivative, such as I11 which, though somewhat less toxic than 11, retained a high order of activity. Later, Stevens and Beute14 showed that the introduction of nuclear alkyl groups considerably increased the toxicity in mice of the comparatively inactive 4-dimethylaminophenol derivatives higher ...