A Convenient New Synthesis of 3??Substituted β??Lactams Formally Derived from 1??(Aminomethyl) cyclopropanecarboxylic Acids

…, SI Kozhushkov, A Brandi, A de Meijere

Index: Zanobini, Alessandra; Gensini, Martina; Magull, Joerg; Vidovic, Denis; Kozhushkov, Sergei I.; Brandi, Alberto; De Meijere, Armin European Journal of Organic Chemistry, 2004 , # 20 p. 4158 - 4166

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Citation Number: 15

Abstract

Abstract 1, 3-Dipolar cycloaddition of N-benzyl-C-(methoxycarbonyl) nitrone (3a), N-benzyl- C-phenylnitrone (3b), N-benzyl-C-cyanonitrone (3c), N-(p-methoxybenzyl)-C-cyanonitrone (3d), N-phenyl-(3e) and N-(2-pyridyl)-C-methylnitrones (3f) to bicyclopropylidene (2) gave the corresponding cycloadducts 5a− f in 100, 95, 94, 100, 93 and 71% yields, respectively. Treatment of these bisspirocyclopropanated isoxazolidines with trifluoroacetic acid in ...

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