Highly regioselective catalytic oxidative coupling reactions: synthetic and mechanistic investigations

KL Hull, EL Lanni, MS Sanford

Index: Hull, Kami L.; Lanni, Erica L.; Sanford, Melanie S. Journal of the American Chemical Society, 2006 , vol. 128, # 43 p. 14047 - 14049

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Citation Number: 263

Abstract

A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed CH activation ...