Total synthesis and structure–activity relationships of caspofungin-like macrocyclic antifungal lipopeptides

J Yao, H Liu, T Zhou, H Chen, Z Miao, G Dong, S Wang…

Index: Yao, Jianzhong; Liu, Hongming; Zhou, Ting; Chen, Hai; Miao, Zhenyuan; Dong, Guoqiang; Wang, Shengzheng; Sheng, Chunquan; Zhang, Wannian Tetrahedron, 2012 , vol. 68, # 14 p. 3074 - 3085

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Citation Number: 7

Abstract

The echinocandins represent a well-known class of macrocyclic antifungal lipopeptides that can be used for treatment of invasive fungal infections. Due to their complex chemical structures and synthetic difficulties, the structure–activity relationships (SARs) of them are still limited. A total synthetic approach was developed to synthesize structurally diverse caspofungin-like antifungal cyclic lipopeptides, allowing for systemically investigating their ...