Direct Nucleophilic Addition to N??Alkoxyamides

Y Yanagita, H Nakamura, K Shirokane…

Index: Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka Chemistry - A European Journal, 2013 , vol. 19, # 2 p. 678 - 684

Full Text: HTML

Citation Number: 25

Abstract

Abstract While the synthesis of amide bonds is now one of the most reliable organic reactions, functionalization of amide carbonyl groups has been a long-standing issue due to their high stability. As an ongoing program aimed at practical transformation of amides, we developed a direct nucleophilic addition to N-alkoxyamides to access multisubstituted amines. The reaction enabled installation of two different functional groups to amide ...

Related Articles:

Cp∗ Ir-catalyzed N-alkylation of amines with alcohols. A versatile and atom economical method for the synthesis of amines

[Fujita, Ken-ichi; Enoki, Youichiro; Yamaguchi, Ryohei Tetrahedron, 2008 , vol. 64, # 8 p. 1943 - 1954]

More Articles...