Tetrahedron letters

Direct reductive amination of carbonyl compounds using bis (triphenylphosphine) copper (I) tetrahydroborate

MJ Bhanushali, NS Nandurkar, MD Bhor…

Index: Bhanushali, Mayur J.; Nandurkar, Nitin S.; Bhor, Malhari D.; Bhanage, Bhalchandra M. Tetrahedron Letters, 2007 , vol. 48, # 7 p. 1273 - 1276

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Citation Number: 43

Abstract

A direct reductive amination protocol for aldehydes/ketones using bis (triphenylphosphine) copper (I) tetrahydroborate as a novel reducing agent in the presence of sulfamic acid has been developed. The reagent chemoselectively reduces the imine moiety and does not affect other reducible functionalities such as chloro, nitro, cyano and methoxy.

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