Hydroboration–azide alkylation as efficient tandem reactions for the synthesis of chiral non racemic substituted pyrrolidines

A Salmon, B Carboni

Index: Salmon, Anne; Carboni, Bertrand Journal of Organometallic Chemistry, 1998 , vol. 567, # 1-2 p. 31 - 37

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Citation Number: 14

Abstract

Pyrrolidines are an important class of five-membered heterocycles with remarkable biological properties [1]. In addition to pharmaceutical applications, the pyrrolidine moiety has also seen wide use as a chiral auxiliary for asymmetric synthesis [2]. Accordingly, development of efficient general methods for the preparation of chiral, non racemic pyrrolidines is of significant value and an increasing number of papers and reports recently appeared in the literature [3]. ...