Inhibitors of blood platelet aggregation. Effects of some 1, 2-benzisothiazol-3-ones on platelet responsiveness to adenosine diphosphate and collagen

KH Baggaley, PD English, LJA Jennings…

Index: Baggaley; English; Jennings; Morgan; Nunn; Tyrrell Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1661 - 1667

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Citation Number: 19

Abstract

A series of substituted 1, 2-benzisothiazol-3-ones was synthesized, and the compounds were tested for ability to inhibit platelet aggregation induced by adenosine diphosphate and collagen in rata and guinea pigs ex vivo. Alkyl substituents at the 2-position bearing a basic group were necessary for ex vivo activity. Several of the compounds were potent inhibitors of adenosine diphosphate induced first-phase aggregation, but adverse toxicological ...