Synthesis, mechanism of action, and QSAR of herbicidal 3??substituted??2??aryl??4, 5, 6, 7??tetrahydroindazoles

JW Lyga, RM Patera, MJ Plummer, BP Halling…

Index: Lyga, John W.; Patera, Russel M.; Plummer, Marjorie J.; Halling, Blaik P.; Yuhas, Debra A. Pesticide Science, 1994 , vol. 42, # 1 p. 29 - 36

Full Text: HTML

Citation Number: 70

Abstract

Abstract A factorially designed set of 3-substituted 2-aryl-4, 5, 6, 7-tetrahydroindazoles was synthesized and their herbicidal properties were evaluated using regression analysis. For optimal activity, the substituent at position 3 should be neither strongly hydrophobic nor hydrophilic and should have a small minimum radius. A study of the mechanism of action indicated that the tetrahydroindazoles are inhibitors of the enzyme protoporphyrinogen ...