Synlett

An expedient route to 3-chlorothioxanthen-9-one-10, 10-dioxide and derivation by palladium-catalyzed coupling

PMJ Lory, A Agarkov, SR Gilbertson

Index: Lory, Pedro M. J.; Agarkov, Anton; Gilbertson, Scott R. Synlett, 2006 , # 18 p. 3045 - 3048

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Citation Number: 6

Abstract

Abstract Chemistry has been developed that allows for the synthesis of a series of novel tricyclic thioxanthen-9-one-10, 10-dioxides. A regioselective synthesis of the novel core substrate 3-chlorothioxanthen-9-one-10, 10-dioxide was achieved in 85% yield over three steps without the need for chromatographic purification. Subsequent microwave-assisted coupling methodology afforded the desired novel 3-substituted tricyclic compounds in ...