Silver-Mediated Palladium-Catalyzed Direct C− H Arylation of 3-Bromoisothiazole-4-carbonitrile

HA Ioannidou, PA Koutentis

Index: Ioannidou, Heraklidia A.; Koutentis, Panayiotis A. Organic Letters, 2011 , vol. 13, # 6 p. 1510 - 1513

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Citation Number: 14

Abstract

Silver (I) fluoride-mediated Pd-catalyzed C− H direct arylation/heteroarylation of 3- bromoisothiazole-4-carbonitrile (1a) gives twenty-four 5-aryl/heteroaryl-3-bromoisothiazole- 4-carbonitriles. The reaction was partially optimized with respect to catalyst, ligand, and base. During this study 3, 3′-dibromo-5, 5′-biisothiazole-4, 4′-dicarbonitrile (3a) was isolated as a byproduct and subsequently prepared via the silver-mediated Pd-catalyzed ...