Thiophene bioisosteres of spirocyclic σ receptor ligands. 1. N-substituted spiro [piperidine-4, 4′-thieno [3, 2-c] pyrans]
C Oberdorf, D Schepmann, JM Vela…
Index: Yoo, Kyung Ho; Choi, Hyun Sik; Kim, Dong Chan; Shin, Kye Jung; Kim, Dong Jin; Song, Yun Seon; Jin, Changbae Archiv der Pharmazie, 2003 , vol. 336, # 4-5 p. 208 - 215
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Citation Number: 47
Abstract
... Institut für Pharmazeutische and Medizinische Chemie der Universität Münster ... postulated a σ 1 receptor model with two transmembrane regions and both the C-and N-termini localized intracellularly.(9) In 2003, σ 1 knockout mice were generated, which are viable and fertile but ...
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