An intramolecular cycloaddition approach to pyrrolo [3, 2-c] quinolones

Y He, H Mahmud, BR Wayland, HVR Dias, CJ Lovely

Index: He, Yong; Mahmud, Hossen; Wayland, Brian R; Dias, H.V.Rasika; Lovely, Carl J Tetrahedron Letters, 2002 , vol. 43, # 7 p. 1171 - 1174

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Citation Number: 30

Abstract

An approach to pyrrolo [3, 2-c] quinolones is described which relies on an intramolecular azomethine ylide alkene cycloaddition reaction. Critical to the success of this reaction was the requirement for alkylation of the aniline nitrogen, in the absence of this substituent a decarboxylative-Michael addition pathway was observed.