A synthesis of functionalized indoline 2, 2-biscarboxylates

SW Wright, RL Dow, LD McClure, DL Hageman

Index: Wright, Stephen W.; Dow, Robert L.; McClure, Lester D.; Hageman, David L. Tetrahedron Letters, 1996 , vol. 37, # 39 p. 6965 - 6968

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Citation Number: 4

Abstract

A synthetic approach to a structurally novel series of indoline 2, 2-biscarboxylates is described that employs a tandem bis-alkylation strategy to cyclize the indoline heteroring from the bromide 7 and diethyl bromomalonate. The indolines thus prepared may be N- deprotected and further functionalized on the indoline nitrogen.