Synthesis and antiviral evaluation of D4T analogues with a spacer arm between glucidic and base moieties

V Roy, R Zerrouki, P Krausz, S Schmidt…

Index: Roy, Vincent; Zerrouki, Rachida; Krausz, Pierre; Schmidt, Sylvie; Aubertin, Anne Marie Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 10 p. 1625 - 1637

Full Text: HTML

Citation Number: 7

Abstract

The synthesis of a series of d4T analogues bearing an acyclic chains between the sugar and the base moities, is described. New compounds were obtained readily using microwave irradiation and selective deprotection of sugar part. The compounds were characterized by 1H NMR and IR spectroscopy. Antiviral (HIV??1) properties of these compounds were examined.