Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of an o-Nitrobenzenesulfonyl Group

…, M Inai, T Asakawa, Y Hamashima, H Sajiki, T Kan

Index: Kawanishi, Akinori; Miyamoto, Chiyako; Yabe, Yuki; Inai, Makoto; Asakawa, Tomohiro; Hamashima, Yoshitaka; Sajiki, Hironao; Kan, Toshiyuki Organic Letters, 2013 , vol. 15, # 6 p. 1306 - 1309

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Citation Number: 8

Abstract

Chemoselective hydrogenation of unsaturated compounds bearing an o- nitrobenzenesulfonyl (Ns)-amide moiety, affording the corresponding saturated compounds, was accomplished efficiently without loss of the nitro group by using the Pd/MS3A catalyst and a H2 balloon. Partial hydrogenation of alkynes bearing an Ns group to corresponding cis alkenes was achieved with the combination of the Pd/BN catalyst and an additive ( ...