Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists

GZ Zheng, P Bhatia, J Daanen, T Kolasa…

Index: Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7374 - 7388

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Citation Number: 62

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Variation at the P1 moiety (N3-substitutent) of the triazafluorenone pharmacophore with both aryl and alkyl groups required synthetic methods to accommodate the SAR studies. ...