Tetrahedron Letters

An efficient sequential one-pot base mediated C–O and Pd-mediated C–C bond formation: synthesis of functionalized cinnamates and isochromenes

AGK Reddy, J Krishna, G Satyanarayana

Index: Gopi Krishna Reddy; Krishna; Satyanarayana Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5635 - 5640

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Citation Number: 21

Abstract

An efficient sequential one-pot intermolecular oxy-Michael addition and intermolecular Heck coupling for the synthesis of functionalized cinnamates is presented. Bulky tert-butyl acrylate was identified as a more suitable Michael acceptor for initial oxy-Michael addition, as it precludes the formation of undesired cross condensed ester. Most importantly, the present method was further divergently extended to the successful synthesis of isochromenes via ...

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