Tetrahedron Letters

A general method for regioselective Heck arylation of electron-rich N-acyl-N-vinylamine with aryl halides

Z Liu, D Xu, W Tang, L Xu, J Mo, J Xiao

Index: Liu, Zhihua; Xu, Dan; Tang, Weijun; Xu, Lijin; Mo, Jun; Xiao, Jianliang Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2756 - 2760

Full Text: HTML

Citation Number: 24

Abstract

A highly efficient protocol for the Pd-catalyzed regioselective Heck arylation of the electron- rich olefin N-acyl-N-vinylamine with aryl halides has been developed. In the presence of hydrogen-bond donor [H2NiPr2][BF4] as an additive, this proceeds smoothly in isopropanol to afford exclusively the branched products in high yields.

Related Articles:

Ruthenium-Catalyzed Hydrovinylation of N-Acetylenamines Leading to Amines with a Quaternary Carbon Center

[Wang, Qiu-Shi; Xie, Jian-Hua; Li, Wei; Zhu, Shou-Fei; Wang, Li-Xin; Zhou, Qi-Lin Organic Letters, 2011 , vol. 13, # 13 p. 3388 - 3391]

Ruthenium-Catalyzed Hydrovinylation of N-Acetylenamines Leading to Amines with a Quaternary Carbon Center

[Wang, Qiu-Shi; Xie, Jian-Hua; Li, Wei; Zhu, Shou-Fei; Wang, Li-Xin; Zhou, Qi-Lin Organic Letters, 2011 , vol. 13, # 13 p. 3388 - 3391]

More Articles...