Ruthenium??Catalyzed Asymmetric Hydrogenation of β??Keto??enamines: An Efficient Approach to Chiral γ??Amino Alcohols

H Geng, X Zhang, M Chang, L Zhou…

Index: Geng, Huiling; Zhang, Xiaowei; Chang, Mingxin; Zhou, Le; Wu, Wenjun; Zhang, Xumu Advanced Synthesis and Catalysis, 2011 , vol. 353, # 16 p. 3039 - 3043

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Citation Number: 4

Abstract

Abstract A highly efficient and enantioselective hydrogenation of unprotected β- ketoenamines catalyzed with ruthenium (II) dichloro {(S)-(−)-2, 2′-bis [di (3, 5-xylyl) phosphino]-1, 1′-binaphthyl}[(2S)-(+)-1, 1-bis (4-methoxyphenyl)-3-methyl-1, 2- butanediamine]{Ru [(S)-xylbinap][(S)-daipen] Cl 2} has been successfully developed. This methodology provides a straightforward access to free γ-secondary amino alcohols, which ...