A useful, regiospecific synthesis of isoxazoles

GN Barber, RA Olofson

Index: Barber,G.N.; Olofson,R.A. Journal of Organic Chemistry, 1978 , vol. 43, p. 3015 - 3021

Full Text: HTML

Citation Number: 70

Abstract

To compare the intramolecular assistance of ester hydrolysis with the intermolecular process, the hydrolysis of 0.075 M 0-methyloxime of DKP in the presence of 0.075 M acetone oxime at pH 7.5 (0.2 M phosphate) was studied. After 2143 h no ester hydrolysis was detected, although about 16% of the acetone oxime had hydrolyzed. Since about 5% ester hydrolysis could have been detected, the effective molaritys of the oxime hydroxyl ...