Tetrahedron letters

NMR determination of the absolute configuration of chiral 1, 2-and 1, 3-diols

H Fukui, Y Fukushi, S Tahara

Index: Fukui, Hiroki; Fukushi, Yukiharu; Tahara, Satoshi Tetrahedron Letters, 2003 , vol. 44, # 21 p. 4063 - 4065

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Citation Number: 24

Abstract

Each of the chiral 1, 2-and 1, 3-diols examined was derivatized exclusively to a single diastereomeric acetal by the use of a new axially chiral reagent, 2′-methoxy-1, 1′- binaphthalene-8-carbaldehyde (MBC). The absolute configuration of the original 1, 2-and 1, 3-diols was determined by the NOE correlation between the proton signals of the reagent moiety and those of the diol moiety in the acetals.