Synthesis of 4-methyl-thio-phenyl-propylamine and the evaluation of its interaction with different amine oxidases

A Gallardo-Godoy, M Hernandez, E Sanz…

Index: Gallardo-Godoy, Alejandra; Hernandez, Mar; Sanz, Elisenda; Unzeta, Mercedes Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 273 - 279

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Citation Number: 8

Abstract

A new molecule, the 4-methyl-thio-phenyl-propylamine (PrNH2) was synthesized and its biological interaction with different amine oxidases such as semicarbazide sensitive amine oxidase (SSAO)[EC 1.4. 3.6], and monoamine oxidase [EC 1.4. 3.4] under its two isoforms, MAO A and MAO B, has been assessed. The substrate specifities of MAO and SSAO overlap to some extent. In this context, the search of new molecules, able to discriminate between ...