A new nonsteroidal analgesic-antiinflammatory agent. Synthesis and activity of 4-ethoxy-2-methyl-5-morpholino-3 (2H)-pyridazinone and related compounds

M Takaya, M Sato, K Terashima…

Index: Takaya,M. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 53 - 58

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Citation Number: 67

Abstract

3 (2H)-pyridazinone (8) was evaluated to be the most attractive compound as an analgesic- antiinflammatory agent. Compound 8 was shown to be more potent in analgesic and antiinflammatory activities and less potent in toxicity than aminopyrine and phenylbutazone. Some pyridazinone derivatives in which possible active sites of 8 are eliminated and altered were prepared, and their activities were evaluated by means of analogous assays. On the ...