Pivaloylpyruvic acid as a new acylating reagent for amines

…, ES Berezina, EN Koz'minykh, YS Kasatkina

Index: Koz'minykh; Igidov; Berezina; Kasatkina Russian Chemical Bulletin, 2000 , vol. 49, # 9 p. 1552 - 1556

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Abstract

Abstract Pivaloylpyruvic acid is an efficient reagent for preparative acylation of amines. A method for the synthesis of substituted pivaloylpyruvamides with domination of (Z)-β-keto- enol tautomer is proposed. The structure of pivaloylpyruvic acid and its amides, as well as the specific features of the reaction of pivaloylpyruvic acid with amines, are discussed.