Journal of medicinal chemistry

New synthetic routes to tilorone dihydrochloride and some of its analogs

HM Burke, MM Joullie

Index: Burke,H.M.; Joullie,M.M. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 1084 - 1086

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Citation Number: 11

Abstract

In summary, the methyl-and bromo-substituted compounds behave similarly, indicating that steric factors are more significant to the activity than electronic forces. The inactivity of the 2, 3-disubstituted derivatives 3b and 3c may be explained by the steric interaction between the 3-substituent and the 2-methoxyl which may force the methoxyl group to interfere with the interaction of the $-hydroxyl group and the receptor. It is of interest that some 2- ...