Enantioselective preparation of asymmetrically protected 2-propanoyl-1, 3-propanediol derivatives: toward the total synthesis of Kazusamycin A

…, N Chikaraishi, M Ikawa, S Ōmura, I Kuwajima

Index: Arai, Noriyoshi; Chikaraishi, Noriko; Ikawa, Mitsuhiro; Omura, Satoshi; Kuwajima, Isao Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 733 - 741

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Citation Number: 6

Abstract

The preparation of enantiomerically pure 2-propanoyl-1, 3-propanediol derivatives, key intermediates in our studies on total synthesis of the potent antitumor compound Kazusamycin A are described. After various enzymatic protocols for desymmetrization of the prochiral diol were studied, it was found that these compounds could be prepared in 97– 98% ee by means of an enzymatic kinetic resolution.