Journal of medicinal chemistry

Inhibition of human alcohol dehydrogenases by formamides

JF Schindler, KB Berst, BV Plapp

Index: Schindler, John F.; Berst, Kristine B.; Plapp, Bryce V. Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1696 - 1701

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Citation Number: 28

Abstract

Human alcohol dehydrogenase (Hs ADH) comprises class I (α, β, and γ), class II (π), and class IV (σ) enzymes. Selective inhibitors of the enzymes could be used to prevent the metabolism of alcohols that form toxic products. Formamides are unreactive analogues of aldehydes and bind to the enzyme-NADH complex [Ramaswamy, S.; Scholze, M.; Plapp, BV Biochemistry 1997, 36, 3522-3527]. They are uncompetitive inhibitors against varied ...