A Non-enzymatic Duplication of the “Fatty Acid Cycle” 1

JC Sheehan, CW Beck

Index: Sheehan; Beck Journal of the American Chemical Society, 1955 , vol. 77, p. 4875

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Citation Number: 8

Abstract

The “fatty acid cycle,” which governs fat metabolism in vivo, has been duplicated using simplified model compount s containing the structural elements which are considered important to the activity of coenzyme A. The reactions i dude Claisen-type self-condensation of N, S-diacetylthioethanolamine (I) to N-acetyl-S-acetoacetylthioethanolamine (I1 [), reduction of the latter to N-acetyl-S-/3-hydroxybutyrylthioethanolamine(IV), dehydration of ...