Tetrahedron: Asymmetry

Asymmetric acyloin condensation catalysed by phenylpyruvate decarboxylase. Part 2: Substrate specificity and purification of the enzyme

Z Guo, A Goswami, VB Nanduri, RN Patel

Index: Guo, Zhiwei; Goswami, Animesh; Nanduri, Venkata B.; Patel, Ramesh N. Tetrahedron Asymmetry, 2001 , vol. 12, # 4 p. 571 - 577

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Citation Number: 29

Abstract

Phenylpyruvate decarboxylase from Achromobacter eurydice was used to catalyse the asymmetric acyloin condensation of phenylpyruvate 1 with various aldehydes 2 to produce optically active acyloins PhCH2COCH (OH) R 3. The specific activity of the phenylpyruvate decarboxylase enzyme was increased by a factor of 332 after its purification. The molecular weight of the purified enzyme was shown to be 150 kDa by gel filtration chromatography, ...

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