Synthesis of ortho-functionalized 4-aminomethylpyridazines as substrate-like semicarbazide-sensitive amine oxidase inhibitors

N Haider, I Hochholdinger, P Mátyus…

Index: Haider, Norbert; Hochholdinger, Iris; Matyus, Peter; Wobus, Andrea Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 7 p. 964 - 970

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Citation Number: 6

Abstract

A series of 4-aminomethylpyridazines and-pyridazin-3 (2H)-ones (“diaza-benzylamines”), bearing alkylamino side chains in ortho position relative to the CH 2 NH 2 unit, was synthesized by catalytic hydrogenation of the corresponding nitriles in strongly acidic medium. N-Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a ...