Stereoselective Total Synthesis of Phenolic Nonadecanediol

…, S Purushotham Reddy, K Venkatesham…

Index: Chinnababu, Baggu; Purushotham Reddy, Sudina; Venkatesham, Kunuru; Chandra Rao, Dasireddi; Venkateswarlu, Yenamandra Helvetica Chimica Acta, 2014 , vol. 97, # 5 p. 613 - 618

Full Text: HTML

Citation Number: 0

Abstract

Abstract A simple and highly efficient synthetic route has been developed for synthesis of 1- (4-hydroxyphenyl) nonadecane-3, 5-diol (1). The two stereogenic centers were generated by employing proline asymmetric α-hydroxylation (MacMillan α-hydroxylation), Jacobsen's hydrolytic kinetic resolution (HKR), and, finally, Yamaguchi oxirane opening as key steps (Scheme 2).

Related Articles:

Initial structure–activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

[Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513]

Initial structure–activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

[Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513]

Initial structure–activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

[Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513]

An Efficient Process for the Synthesis of γ-Arylbutanals via Copper-Mediated Grignard Coupling

[Monte, William T.; Lindbeck, Aline C. Organic Process Research and Development, 2001 , vol. 5, # 3 p. 267 - 269]

More Articles...