Tetrahedron Letters

Nouvelle synthese simple de nucleoside phosphorothiolate

U Asseline, NT Thuong

Index: Asseline, U.; Thuong, N. T. Tetrahedron Letters, 1981 , vol. 22, p. 847 - 850

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Citation Number: 4

Abstract

Summary. The O, S-dimethylphosphorochloridate 10 reacts with 5'-0- monomethoxytritylthymidine 11 in pyridine giving nucleoside-3'-thiolophosphodzster 13 in high yields: in acetonitrile and z the presence of I-methylimidazole, this reaction leadsto the nucleoside-3'-phosphotriester 14-without formation of diester 13. From the latter, the Tp and TpT have been prepared.

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