Tetrahedron letters

Efficient synthesis of substituted 2-aminopyrazines: FeCl 3-promoted condensation of hydroxyiminoketones with aminoacetonitriles

T Itoh, K Maeda, T Wada, K Tomimoto, T Mase

Index: Itoh, Takahiro; Maeda, Kenji; Wada, Toshihiro; Tomimoto, Koji; Mase, Toshiaki Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9287 - 9290

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Citation Number: 13

Abstract

Substituted pyrazines have gained increased attention in recent years due to their usefulness as important constituents either of biologically active compounds 1., , , , , , and or functional materials. 2 In particular, substituted 2-aminopyrazines are key synthetic intermediates to the luciferins and their analogues, 3 which have long been known as chemiluminescent and/or bioluminescent agents. 4., , , , , , 5., , and Irrespective of their importance, an efficient synthetic route to ...

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