Synthesis of 3-aryl-3-pyridylallylamines related to zimelidine via palladium-catalyzed amination

JE Baeckvall, RE Nordberg, JE Nystroem…

Index: Baeckvall, Jan-E.; Nordberg, Ruth E.; Nystroem, Jan-E.; Hoegberg, Thomas; Ulff, Bengt Journal of Organic Chemistry, 1981 , vol. 46, # 17 p. 3479 - 3483

Full Text: HTML

Citation Number: 35

Abstract

However, all compounds having the pyridyl and nitrogen in a cis relationship have been named the Z isomer.(biphos) produced a mixture of E and 2 isomers of 4. The amination was usually rapid at 55" C, and in most cases the reaction was completed within 1 h. Results from amination of some different acetates 3 are shown in Table I. The acetate 3 was completely unreactive toward amine in the absence of the palladium catalyst. Thus ...