Oxidative aromatization of 1, 4-dihydropyridines and pyrazolines using HbA–H 2 O 2: An efficient biomimetic catalyst system providing metabolites of drug candidates

A Kumar, RA Maurya, S Sharma

Index: Kumar, Atul; Maurya, Ram Awatar; Sharma, Siddharth Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4432 - 4436

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Citation Number: 15

Abstract

Human hemoglobin (HbA) efficiently catalyses the oxidative aromatization of 1, 4- dihydropyridines (1, 4-DHPs) and pyrazolines with hydrogen peroxide in phosphate buffer. The results of the study reveal that the rates of oxidative aromatization of 1, 4-DHPs are substituent dependent. Thus, the present study is very useful in understanding the metabolism of 1, 4-DHP drugs in liver by cytochrome P450 and designing novel drugs as ...