Palladium-and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

Y Nishihara, D Saito, E Inoue, Y Okada, M Miyazaki…

Index: Nishihara, Yasushi; Saito, Daisuke; Inoue, Eiji; Okada, Yoshiaki; Miyazaki, Mikihiro; Inoue, Yoshiaki; Takagi, Kentaro Tetrahedron Letters, 2010 , vol. 51, # 2 p. 306 - 308

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Citation Number: 20

Abstract

Alkynylboronates can be employed as a practical and versatile precursor for a variety of π- conjugated organic compounds. In the presence of Cu (I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions.

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